Product ID:CYTOXAN FOR INJECTION 200 MG/VIAL
MSDS Date:12/22/1993
FSC:6505
NIIN:00F039416
MSDS Number: BWYJP

BRISTOL-MYERS SQUIBB, PHARMACEUTICAL GRP

5 GORDIS RD BLDG 124
NEW BRUNSWICK, NJ 08903-5000
US

Emergency Phone: 908-519-3843/609-921-4081

Info Phone: 800-332-2056/908-519-3843

Cage: BRIST

E R SQUIBB MEDATOPE DIV

191 NEW BRUNSWICK, NJ 08903 US

Telephone: 609-921-4081

Cage: 4T649

CYCLOPHOSPHAMIDE HYDRATE (HUMAN & ANIMAL CARCINOGEN BY

CAS: 6055-19-2

RTECS: RP6157750

Fraction By Weight: 70%

SODIUM CHLORIDE

CAS: 7647-14-5

RTECS: VZ4725000

Fraction By Weight: >1%

LD50 LC50 Mixture:ORAL LD50 (RAT): 94 MG/KG (SEE SUPP)
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:YES OSHA:NO
Health Hazards Acute and Chronic:INHALATION/SKIN/INGESTION: SYSTEMIC
ABSORPTION. SKIN: DELAYED BONE MARROW SUPPRESSION & POSSIBLY
CARDIOTOXICITY. EYES: CONJUNTIVITIS. MAY AFEECT THE GI TRACT,
KIDNEYS, LUNGS, REPRODUCTIVE SYSTEM & HEA RT. THIS DRUG MAY BE
HARMFUL TO THE FETUS. CYCLOPHOSPHAMIDE-BONE MARROW SUPPRESSION,
CARDIOTOXICITY. (SEE SUPP)
Explanation of Carcinogenicity:SEE INGREDIENTS. ACCORDING TO
BRISTOL-MEYERS, CYCLOPHOSPHAMIDE IS A NTP HUMAN CARCINOGEN.
Effects of Overexposure:NAUSEA, VOMITING, ANOREXIA, HEADACHE,
DIZZINESS, RASH. CYCLOPHOSPHAMIDE: NAUSEA, VOMITING, ANOREXIA,
DIARRHEA, HEADACHE, DIZZINESS. SODIUM CHLORIDE: IRRITATION,
SNEEZING, COUGH, DIFFICULTY BREATHING, TIGHTNESS OF CHEST,
REDNESS, TEARING, SWELLING, PAIN.
Medical Cond Aggravated by Exposure:LOW PLATELET/LEUKOCYTE COUNTS,
COAGULATION DISORDERS, RENAL/PULMONARY/CARDIAC DISEASES, RECENT
RADIATION/CHEMOTHERAPY.

First Aid:INGESTION: INDUCE VOMITING IF CONSCIOUS & NOT CONVULSING.
INHALATION: REMOVE TO FRESH AIR. GIVE CPR/OXYGEN IF NEEDED.
SKIN/EYES: FLUSH W/PLENTY OF WATER FOR 15 MINS. OBTAIN MEDICAL
ATTENTION IN ALL CA SES. NOTE TO PHYSICIAN: WHEN
ADMINISTEDPARENTERALLY, IT'S HIGHLY TOXIC W/A LOW THERAPUTIC INDEX.

Extinguishing Media:WATER, CO2, FOAM, DRY CHEMICAL.
Fire Fighting Procedures:WEAR SCBA & FULL PROTECTIVE EQUIPMENT.
EVACUATE PERSONNEL UPWIND. REMOVE UNNEEDED MATERIAL & COOL
CONTAINERS W/WATER FROM A MAXIMUM DISTANCE.
Unusual Fire/Explosion Hazard:FINE DUSTS SUSPENDED IN AIR IN SUFFICIENT
CONCENTRATION & IN PRESENCE OF AN IGNITION SOURCE MAY POSE A
POTENTIAL EXPLOSION HAZARD.

Spill Release Procedures:ISOLATE AREA & WEAR SUITABLE PROTECTIVE
EQUIPMENT. COLLECT W/PAPER TOWELING & MOISTEN PRIOR TO PICK UP TO
MINIMIZE DUST GENERATION. CLEAN AREA USING SEVERAL WASHES
W/DETERGENT & WATER. TREAT PRODUCT/C ONTAMINATED MATERIALS AS
HAZARDOUS WASTE.

Handling and Storage Precautions:STORE AT/<77F. PROTECT FROM TEMPS
EXCEEDING 86F. DON'T BREAK VIALS/SPILL CONTENTS. MINIMIZE DUST
GENERATION.
Other Precautions:AVOID INHALATION/INGESTION/SKIN CONTACT.
DECONTAMINATE PROTECTIVE EQUIPMENT AFTER USE. PROVIDE APPROPRIATE
BONDING & GROUNDING PROTECTION TO CONTROL STATIC CHARGES.

Respiratory Protection:WEAR A NIOSH APPROVED DUST RESPIRATOR W/HIGH
EFFICIENCY DUST FILTER/POWERED AIR-PURIFYING RESPIRATOR WHEN
ENGINEERING CONTROLS AREN'T SUFFICIENT TO CONTROL EXPOSURE. WEAR
SELF CONTAINED BREATHING APPA RATUS IN EMERGENCIES.
Ventilation:LOCAL MECHANICAL EXHAUST: EXPLOSION PROOF. BIOLOGICAL
CABINET SHOULD BE USED FOR PREPARATION OF THIS DRUG.
Protective Gloves:DISPOSABLE SURGICAL LATEX
Eye Protection:CHEMICAL SAFETY GOGGLES
Other Protective Equipment:IMPERVIOUS DISPOSABLE COVERALLS W/CLOSED
FRONT, LONG SLEEVES & ELASTIC CUFFS, BOOTS, EXPLOSION PROOF
EQUIPMENT.
Work Hygienic Practices:REMOVE/LAUNDER CONTAMINATED CLOTHING BEFORE
REUSE. WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health
SOLUBILITY, PH, VAPOR DENSITY & ORAL LD50 INFORMATION IS FOR
CYCLOPHOSPHAMIDE MONOHYDRATE. HEALTH HAZARDS CONT'D:
CYCLOPHOSPHAMIDE-GI EFFECTS/CYSTITIS/KIDNEY
DAMAGE/ALOPECIA/PULMONARY FIBROSIS/CHANGES IN
METABOLISM/CARDIOTOXICITY/POSITIVE FOR MUTAGENICITY &
TERATOGEN/GONADAL SUPPRESSION/PERMANENT STERILITY.

Melt/Freeze Pt:M.P/F.P Text:106-113F
Vapor Density:>1 (SUPP)
pH:3-7.5
Solubility in Water:40 MG/ML (SEE SUPP)
Appearance and Odor:VIAL CONTAINS WHITE POROUS CAKE-LIKE SOLID W/NO
ODOR.

Stability Indicator/Materials to Avoid:YES
STRONG OXIDIZERS.
Stability Condition to Avoid:TEMPS >86F, IGNITION SOURCES.
Hazardous Decomposition Products:CO, CO2, CHLORINE, HYDROGEN CHLORIDE,
OXIDES OF NITROGEN & PHOSPHOROUS, PHOSPHINE.
Conditions to Avoid Polymerization:TEMPS >120.2F.

Waste Disposal Methods:DISPOSE OF IAW/FEDERAL, STATE & LOCAL
REGULATIONS. SHOULD BE INCINERATED AT AN APPROVED FACILITY.
POISONOUS UN2811.

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